模板:PBB/5728

{{GNF_Protein_box
 | Name = 磷酸酯酶與張力蛋白同源物
 | image = Pten.jpg
 | image_source = 人PTEN的晶體結(jié)構(gòu)圖。[[N-端]]磷酸酯酶結(jié)構(gòu)域以藍色表示而[[C-端]][[C2結(jié)構(gòu)域]]以紅色表示<ref name="pmid10555148">{{PDB|1d5r}}；{{cite journal | author = Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP | title = Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | journal = Cell | volume = 99 | issue = 3 | pages = 323–34 | year = 1999 | month = October | pmid = 10555148 | doi = 10.1016/S0092-8674(00)81663-3  | url = | issn = }}</ref>。
 | PDB = {{PDB2|1D5R}}, {{PDB2|2KYL}}
 | HGNCid = 9588
 | MGIid = 109583
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | Symbol = PTEN
 | AltSymbols =; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
 | IUPHAR = 
 | ChEMBL = 
 | OMIM = 601728
 | ECnumber = 3.1.3.16, 3.1.3.48, 3.1.3.67
 | Homologene = 265
 | GeneAtlas_image1 = 
 | GeneAtlas_image2 = 
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004438 |text = phosphatidylinositol-3-phosphatase activity}} {{GNF_GO|id=GO:0004721 |text = phosphoprotein phosphatase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008138 |text = protein tyrosine/serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0010997 |text = anaphase-promoting complex binding}} {{GNF_GO|id=GO:0016314 |text = phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0051717 |text = inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity}} {{GNF_GO|id=GO:0051800 |text = phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity}}
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009898 |text = internal side of plasma membrane}} {{GNF_GO|id=GO:0016605 |text = PML body}} {{GNF_GO|id=GO:0035749 |text = myelin sheath adaxonal region}} {{GNF_GO|id=GO:0042995 |text = cell projection}} {{GNF_GO|id=GO:0043005 |text = neuron projection}} {{GNF_GO|id=GO:0043220 |text = Schmidt-Lanterman incisure}}
 | Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001933 |text = negative regulation of protein phosphorylation}} {{GNF_GO|id=GO:0002902 |text = regulation of B cell apoptotic process}} {{GNF_GO|id=GO:0006470 |text = protein dephosphorylation}} {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0006661 |text = phosphatidylinositol biosynthetic process}} {{GNF_GO|id=GO:0006915 |text = apoptotic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007092 |text = activation of mitotic anaphase-promoting complex activity}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007270 |text = neuron-neuron synaptic transmission}} {{GNF_GO|id=GO:0007416 |text = synapse assembly}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007611 |text = learning or memory}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008543 |text = fibroblast growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0010975 |text = regulation of neuron projection development}} {{GNF_GO|id=GO:0014067 |text = negative regulation of phosphatidylinositol 3-kinase cascade}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0021542 |text = dentate gyrus development}} {{GNF_GO|id=GO:0021955 |text = central nervous system neuron axonogenesis}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0031642 |text = negative regulation of myelination}} {{GNF_GO|id=GO:0031647 |text = regulation of protein stability}} {{GNF_GO|id=GO:0031658 |text = negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S}} {{GNF_GO|id=GO:0032286 |text = central nervous system myelin maintenance}} {{GNF_GO|id=GO:0032535 |text = regulation of cellular component size}} {{GNF_GO|id=GO:0033032 |text = regulation of myeloid cell apoptotic process}} {{GNF_GO|id=GO:0033555 |text = multicellular organismal response to stress}} {{GNF_GO|id=GO:0035176 |text = social behavior}} {{GNF_GO|id=GO:0035335 |text = peptidyl-tyrosine dephosphorylation}} {{GNF_GO|id=GO:0042711 |text = maternal behavior}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptotic process}} {{GNF_GO|id=GO:0043491 |text = protein kinase B signaling cascade}} {{GNF_GO|id=GO:0043542 |text = endothelial cell migration}} {{GNF_GO|id=GO:0043647 |text = inositol phosphate metabolic process}} {{GNF_GO|id=GO:0044281 |text = small molecule metabolic process}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045475 |text = locomotor rhythm}} {{GNF_GO|id=GO:0045792 |text = negative regulation of cell size}} {{GNF_GO|id=GO:0046621 |text = negative regulation of organ growth}} {{GNF_GO|id=GO:0046855 |text = inositol phosphate dephosphorylation}} {{GNF_GO|id=GO:0046856 |text = phosphatidylinositol dephosphorylation}} {{GNF_GO|id=GO:0048011 |text = neurotrophin TRK receptor signaling pathway}} {{GNF_GO|id=GO:0048015 |text = phosphatidylinositol-mediated signaling}} {{GNF_GO|id=GO:0048738 |text = cardiac muscle tissue development}} {{GNF_GO|id=GO:0048853 |text = forebrain morphogenesis}} {{GNF_GO|id=GO:0048854 |text = brain morphogenesis}} {{GNF_GO|id=GO:0050680 |text = negative regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0050771 |text = negative regulation of axonogenesis}} {{GNF_GO|id=GO:0050821 |text = protein stabilization}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0051091 |text = positive regulation of sequence-specific DNA binding transcription factor activity}} {{GNF_GO|id=GO:0051895 |text = negative regulation of focal adhesion assembly}} {{GNF_GO|id=GO:0051898 |text = negative regulation of protein kinase B signaling cascade}} {{GNF_GO|id=GO:0060024 |text = rhythmic synaptic transmission}} {{GNF_GO|id=GO:0060070 |text = canonical Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0060074 |text = synapse maturation}} {{GNF_GO|id=GO:0060134 |text = prepulse inhibition}} {{GNF_GO|id=GO:0060179 |text = male mating behavior}} {{GNF_GO|id=GO:0060291 |text = long-term synaptic potentiation}} {{GNF_GO|id=GO:0060736 |text = prostate gland growth}} {{GNF_GO|id=GO:0060997 |text = dendritic spine morphogenesis}} {{GNF_GO|id=GO:0061002 |text = negative regulation of dendritic spine morphogenesis}} {{GNF_GO|id=GO:0090071 |text = negative regulation of ribosome biogenesis}} {{GNF_GO|id=GO:0090344 |text = negative regulation of cell aging}} {{GNF_GO|id=GO:0090394 |text = negative regulation of excitatory postsynaptic membrane potential}} {{GNF_GO|id=GO:0097105 |text = presynaptic membrane assembly}} {{GNF_GO|id=GO:0097107 |text = postsynaptic density assembly}} {{GNF_GO|id=GO:2000060 |text = positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:2000134 |text = negative regulation of G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:2000463 |text = positive regulation of excitatory postsynaptic membrane potential}} {{GNF_GO|id=GO:2000808 |text = negative regulation of synaptic vesicle clustering}}
 | Hs_EntrezGene = 5728
 | Hs_Ensembl = ENSG00000171862
 | Hs_RefseqmRNA = NM_000314
 | Hs_RefseqProtein = NP_000305
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 10
 | Hs_GenLoc_start = 89622870
 | Hs_GenLoc_end = 89731687
 | Hs_Uniprot = P60484
 | Mm_EntrezGene = 19211
 | Mm_Ensembl = ENSMUSG00000013663
 | Mm_RefseqmRNA = NM_008960
 | Mm_RefseqProtein = NP_032986
 | Mm_GenLoc_db = mm9
 | Mm_GenLoc_chr = 19
 | Mm_GenLoc_start = 32757497
 | Mm_GenLoc_end = 32826160
 | Mm_Uniprot = O08586
 | path = PBB/5728
}}<noinclude>

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