血栓素A2是一種血栓素，常用作血管收縮劑，可以激活血小板、使其聚集，是治愈組織損傷和發(fā)炎的常用藥。但也會導(dǎo)致心絞痛。
血栓素A2通過血栓素A合酶由前列腺素H2產(chǎn)生，在水溶液中極不穩(wěn)定，30秒內(nèi)將水解成血栓素B2。因此主要以組織附近的自分泌或旁分泌中介的方式作用。而其相關(guān)研究也是用類似物U46619和I-BOP來做的。[1] 人體實驗中，依照11去氫血栓烷B2的等級來測試血栓素A2的產(chǎn)生。[2][3]
參考文獻(xiàn)
- ↑ Michael P. Walsh, et all. Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697.
- ↑ Catella F, Healy D, Lawson JA, FitzGerald GA. 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. PNAS. 1986, 83 (16): 5861–5865. doi:10.1073/pnas.83.16.5861. PMID 3461463. PMC 386396.
- ↑ Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J. 2007, 28 (14): 1702–1708. doi:10.1093/eurheartj/ehm226. PMID 17569678.
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